Episodes: 106
Frequency: Weekly
Rating: 4.3/5.0
Estimated listeners: 1k-10k
Gender skew: Male
Location: USA
Publicly listed emails
podcast@sequoiacap.com
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Sonya Huang - Sequoia Capital partner focused on investing in artificial intelligence and software companies.
Pat Grady - Sequoia Capital partner and investor focused on technology companies, particularly enterprise software.
Lauren Reeder - Sequoia Capital partner focused on artificial intelligence and technology investing.
Alfred Lin - Sequoia Capital partner and technology investor; formerly an executive at Zappos.
Matan Grinberg - Autonomous Coding Agents, Developer Tools, Model-agnostic AI Harnesses, Open-weight Models, And The Future Of Software Development.
Angela Jiang - AI Developer Platforms, Agent Architecture, Coordination Strategies, Ecosystem Standards, MCP, And Harness Design.
Katelyn Lesse - AI Developer Platforms, Managed Agents, Execution Harnesses, Ecosystem Standards, MCP, And Open Versus Closed AI Ecosystems.
Eric Watson - Autonomous-system Safety, Flight Systems, Engineering Reliability, Air-traffic Integration, And Drone Delivery Operations.
Keller Rinaudo Cliffton - Autonomous Delivery Systems, Drone Logistics, Safety Engineering, Healthcare Delivery, And Scaling Commercial Autonomous Operations.
Rich Sutton and Khurram Javed: Why AI Models Stop Learning, and How to Start It Again
August 18, 2026
Rich Sutton, who helped pioneer reinforcement learning and wrote the seminal AI essay The Bitter Lesson, has now cofounded Oak Lab with his former student Khurram Javed. Their goal: to build agents that continuously learn from their own experience rather than from us. Rich doesn't think he holds a radical view: "I'm not weird. The field is weird." He says all learning is continual, and the field is the one that needed a new name for it. Rich and Khurram argue synthetic data is "a big mistake....
Chai Discovery's Bitter Lesson: Drug Design Is Another Scaling Problem
August 04, 2026
Most people treat biology as a bespoke, messy science. Josh Meier and Matt McPartlon, co-founders of Chai Discovery, treat it as an engineering problem. They make the case that drug design obeys the bitter lesson: scale data, models, and compute, and the model can learn what a hand-built pipeline simply couldn't capture. The results are concrete: Chai-2 pushed de novo antibody design from a sub 0.1% hit rate to 16%, turning a needle-in-a-haystack search into something more like designing a ke...
Building the Automated AGI Lab: Core Automation's Jerry Tworek and Rohan Anil
July 29, 2026
Jerry Tworek led reasoning at OpenAI, convinced that scaling reinforcement learning was the path to AGI. Rohan Anil co-led Gemini pre-training and built the Shampoo optimizer. Now they've teamed up at Core Automation on a contrarian premise: the transformer has carried us as far as it can, and the bottleneck to smarter systems is no longer scale — it's the architecture itself. The missing capability is continual learning, models that adapt at test time, which transformers can't do. In-context...
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