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Episodes: 169
Frequency: Weekly
Rating: 4.5/5.0
Estimated listeners: 1k-10k
Gender skew: Male
Location: USA
YouTube: 81.5k subscribers
production@podpeople.com
For verified host and producer emails, sign up to view.
Elad Gil - Serial entrepreneur and startup investor; co-founder of Color Health and Mixer Labs (acquired by Twitter). Has invested in over 40 companies worth $1B+ each, and is author of the High Growth Handbook.
Sarah Guo - Startup investor and founder of Conviction, an investment firm purpose-built to serve intelligent software (“Software 3.0”) companies. Spent nearly a decade incubating and investing at Greylock Par...
Noam Brown - Why Traditional AI Benchmarks Fail; Test-time Compute; AI Evaluation And Safety Frameworks; Recursive Self-improvement; Multi-agent Collaboration
Lip-Bu Tan - Turning Intel Around; Culture And Execution; Balance Sheet Strategy; Cpu/agentic AI And Inference Roadmap; Semiconductor Supply Chain And Investment Perspectives
Alex Rives - Virtual Biology Initiative; Open-source Digital Protein/antibody Design Engine; Translating Mechanistic Simulations Toward Clinical Impact
Priscilla Chan - Biohub Mission And Strategy; Integrating AI With Biology; Open-source Direction For Biological Design
Mark Zuckerberg - Biohub Mission And Strategy; Integrating AI With Biology; Open-source Direction For Biological Design
How Nuclear Will Unlock Energy Abundance with Valar Atomics Founder Isaiah Taylor
July 02, 2026
While the rest of the nuclear industry still relies on simulations and paper designs, Valar Atomics is busy splitting atoms. In fact, they just powered an NVIDIA Blackwell chip directly with a live nuclear reactor in order to power the world’s first nuclear powered website. Sarah Guo joins Valar Atomics founder and CEO Isaiah Taylor on-site at their California headquarters to talk about how Valar is shifting nuclear energy from the theoretical to the practical by building and perfecting react...
Really Big Test-Time Compute in AI Changes Benchmarks, Safety and Research with OpenAI Research Scientist Noam Brown
June 26, 2026
When a new AI model drops, it’s judged based on a static benchmark grid that doesn’t account for how long the model is allowed to think. How then should we measure a model’s true capability? OpenAI research scientist Noam Brown returns to talk with Sarah Guo about his latest essay on why the AI industry’s traditional benchmark grids are broken, and how large-scale test-time compute is fundamentally changing how models are evaluated. Noam explains how, if properly scaffolded, today’s models ca...
Re-engineering the Semiconductor Supply Chain with Intel CEO Lip-Bu Tan
June 18, 2026
At 66 years old, instead of heading towards retirement, former Cadence CEO and legendary investor Lip-Bu Tan decided to take on the hardest job in tech: turning Intel around. Elad Gil and Sarah Guo sit down with Intel CEO Lip-Bu Tan to talk about why he took the job and what “saving” Intel actually looks like. Tan explains how his experience in startup culture informed his decisions to drive Intel’s culture towards faster decisions, focus on customer satisfaction, and engineer accountability....
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