Episodes: 237
Frequency: Weekly
Rating: 4.3/5.0
Estimated listeners: 100 - 1,000
Gender skew: Male
Listener location: Canada
YouTube: 5.7k subscribers
Instagram: 48.0k followers
Publicly listed emails
liron@upfiredigital.com
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Dr. Mike Hart - Physician and health educator focused on evidence-based health, longevity, human performance, hormone health, and modern medicine.
Leigh Erin Connealy, MD - Cancer Prevention, Metabolic Health, Environmental Toxins, Hormones, Fasting, Ketogenic Diets, Screening, Peptides, And Integrative Approaches To Health.
Dan Go - Sustainable Fat Loss, Nutrition, Protein And Fiber, Behavior Change, Time-efficient Strength Training, Muscle Preservation, And Glp-1 Medications.
Charles Brenner, PhD - Nad+ Metabolism, Nicotinamide Riboside, Vitamin B3 Biology, Metabolic Stress, Human Clinical Evidence, And Limitations Of Longevity Claims.
Jonathan Schoeff, MD - Testosterone Screening, Free Testosterone, SHBG, Fertility, Insulin Resistance, Body Composition, Hormone Optimization, And Individualized Treatment.
#241 Decriminalization, Healthcare, and the Future of Medicine with Dr. Ira Price
October 08, 2026
Dr. Mike Hart and Dr. Ira Price explore how medicine is adapting as patients gain greater access to emerging treatments, health information, and tools once limited to physicians. They discuss unapproved peptides and GLP-1 drugs, the growing shift toward personalized and patient-centered care, and the challenges doctors face when evidence and regulation lag behind real-world use. The conversation expands into Canada's opioid crisis, drug decriminalization, fentanyl and medetomidine contaminati...
#240 Dr. Spencer Nadolsky on Repatha, ApoB Targets, and What Actually Matters in Lipidology
October 01, 2026
Dr. Mike Hart sits down with lipidologist Dr. Spencer Nadolsky for a practical discussion on cardiovascular prevention, cholesterol management, and metabolic health. They break down how to interpret ApoB, LDL, HDL, triglycerides, and Lp(a), when cholesterol-lowering medications may make sense, and why long-term exposure matters when thinking about heart disease risk. The conversation also explores statins, PCSK9 inhibitors, plaque progression, supplements, insulin resistance, and the evolving...
#239 Oral Peptides: How They Work Without Entering the Bloodstream
September 24, 2026
Dr. Mike Hart discusses how oral peptides can still have biological effects despite limited or no systemic absorption, using examples including KPV, BPC-157, linaclotide (Constella), oral semaglutide, and cyclosporine. He explains protein digestion into dipeptides/tripeptides and the PEPT1 transporter that moves some small peptides into enterocytes for local cellular effects, noting that KPV can act in intestinal cells without entering circulation and that carnosine is another PEPT1-absorbed ...
5 Codes Podcast · Low booking difficulty · 100 - 1,000 listeners
Hart2Heart with Dr. Mike Hart is hosted by Dr. Mike Hart. Its publicly listed email is liron@upfiredigital.com. For guest bookings, the host or producer is usually the best person to reach. Podseeker helps you find direct host and producer contacts and pitch from your own inbox.
The publicly listed email for Hart2Heart with Dr. Mike Hart: liron@upfiredigital.com.
Podseeker estimates Hart2Heart with Dr. Mike Hart reaches 100 to 1,000 listeners per episode. Only the publisher has exact numbers.
Hart2Heart with Dr. Mike Hart typically books industry leaders. Typical guest background: Medical specialists, researchers, longevity and performance practitioners, fitness professionals, and health entrepreneurs with substantial subject-matter expertise and practical experience. Common among recent guests: Peer-reviewed research or recognized scientific expertise; Medical or clinical leadership; Published books or established professional practices. Recent guests include Leigh Erin Connealy, MD, Dan Go, and Charles Brenner, PhD.
Medium. Guests usually need solid credentials in the topic and an idea that fits the show.
Recent episodes cover Longevity, Hormone Health, Metabolic Health, Peptides, and Performance. Pitch an idea tied to one of these topics and mention a recent episode.
Publicly listed emails
liron@upfiredigital.com
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